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Description for Protein ERCC4

excision repair cross-complementing rodent repair deficiency, complementation group 4
10 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6). (PubMed Links)
Domains and Motifs:
  • LZ: Leucine Zipper
  • NLS: Nuclear localization signal
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.-.-
    KEGG - Orthology:
    K10848
    KEGG - Pathway(s):
    hsa03420
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Xeroderma pigmentosum group F complementing protein; DNA excision repair protein ERCC 4; Excision repair complementing defective in chinese hamster 4; DNA repair protein complementing XPF cell; ERCC11; XPF; Excision repair cross complementing rodent repair deficiency complementation group 4; RAD1; DNA repair protein complementing XP F cell
    Approved Symbol:
    ERCC4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Xeroderma pigmentosum, type F(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00594 Entrez Gene ID: 2072 OMIM ID: 133520 Swissprot Accession: Q92889;