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Description for Protein ERCC3

excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing)
24 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
ERCC3 is an ATP-dependent DNA helicase that functions in nucleotide excision repair and complements xeroderma pigmentosum group B mutations. It also is the 89 kDa subunit of basal transcription factor 2 (TFIIH) and thus functions in class II transcription. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • DEXDc: DEAD-like helicases superfamily
  • HELIC: helicase superfamily c-terminal domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.6.1.-
    KEGG - Orthology:
    K10843
    KEGG - Pathway(s):
    hsa03420
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Excision repair complementing defective in chinese hamster 3; Xeroderma pigmentosum group B complementing protein; ERCC 3; XPB; XPBC; BTF2; GTF2H; RAD25; TFIIH 80kda subunit; DNA repair protein complementing XP B cells; TFIIH basal transcription factor complex helicase XPB subunit
    Approved Symbol:
    ERCC3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Trichothiodystrophy(Pd);
  • Xeroderma pigmentosum, type B/Cockayne syndrome(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00593 Entrez Gene ID: 2071 OMIM ID: 133510 Swissprot Accession: P19447; Q53QM0;