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Description for Protein AKT1

v-akt murine thymoma viral oncogene homolog 1
154 total interacting proteins; 78 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
  • PH: Pleckstrin homology domain.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K04456
    KEGG - Pathway(s):
    hsa04010; hsa04012; hsa04062; hsa04150; hsa04210; hsa04370; hsa04510; hsa04530; hsa04620; hsa04630; hsa04660; hsa04662; hsa04664; hsa04666; hsa04722; hsa04910; hsa04914; hsa04920; hsa05142; hsa05200; hsa05210; hsa05211; hsa05212; hsa05213; hsa05214; hsa05215; hsa05218; hsa05220; hsa05221; hsa05222; hsa05223
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Protein kinase B; AKT; Oncogene AKT1; PKB; RAC serine/threonine protein kinase; RAC PK alpha; C-AKT; Protein kinase B alpha; PKB alpha; PRKBA; MGC99656; RAC alpha; RAC protein kinase alpha; RAC alpha serine/threonine protein kinase; EC 2.7.1.37; RAC
    Approved Symbol:
    AKT1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 14
    Human (de-) phosphorylation sites: 14; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 149
    Human phosphorylation targets: 120; Predicted platelet targets: 32
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine(db);
  • Adenosine triphosphate(db);
  • Arsenic trioxide(db);
  • Inositol 1,3,4,5-Tetrakisphosphate(db);
  • N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01261 Entrez Gene ID: 207 OMIM ID: 164730 Swissprot Accession: P31749; B3KVH4; B0LPE5;