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Description for Protein ERBB3

v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
35 total interacting proteins; 16 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • FU: Furin-like repeats
  • REC: cheY-homologous receiver domain
  • TM: Transmembrane domain
  • Tyr_Kinase: tyrosine kinase domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.10.1
    KEGG - Orthology:
    K05084
    KEGG - Pathway(s):
    hsa04012; hsa04020; hsa04144
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    ErbB-3 isoform s precursor; ErbB-3 isoform 1 precursor; Receptor tyrosine protein kinase erbB-3; Tyrosine kinase type cell surface receptor HER3; Oncogene Erb-B3; C-erbB3; HER3; ErbB-3; ErbB3-S; MDA-BF-1; MGC88033; C-erbB-3; P180-ErbB3; P45-sErbB3; P85-sErbB3; EC 2.7.1.112
    Approved Symbol:
    ERBB3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 16
    Human (de-) phosphorylation sites: 16; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 01820 Entrez Gene ID: 2065 OMIM ID: 190151 Swissprot Accession: B3KWG5; P21860;