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Description for Protein ERBB2

v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
64 total interacting proteins; 38 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • FU: Furin-like repeats
  • REC: cheY-homologous receiver domain
  • TM: Transmembrane domain
  • Tyr_Kinase: tyrosine kinase domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.10.1
    KEGG - Orthology:
    K05083
    KEGG - Pathway(s):
    hsa04012; hsa04020; hsa04510; hsa04520; hsa05200; hsa05212; hsa05213; hsa05215; hsa05219; hsa05223
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    ErbB2; NGL; NEU; HER2; TKR1; HER-2; C-erb B2; HER-2/neu; Herstatin; C-erb B2/neu protein; Tyrosine kinase type cell surface receptor; ErbB-2 isoform b; ErbB-2 isoform a
    Approved Symbol:
    ERBB2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 53
    Human (de-) phosphorylation sites: 53; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 6
    Human phosphorylation targets: 6; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Lapatinib(db);
  • Trastuzumab(db)

    Associated Genetic Diseases:

  • Adenocarcinoma of lung, somatic(Pd);
  • Erbb2 polymorphism(Pd);
  • Gastric cancer, somatic(Pd);
  • Glioblastoma, somatic(Pd);
  • Ovarian carcinoma, somatic(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 2
  • Isoform 1 : 2
    • Additional Identifiers:

    HPRD: 01281 Entrez Gene ID: 2064 OMIM ID: 164870 Swissprot Accession: P04626;