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Description for Protein EPRS

glutamyl-prolyl-tRNA synthetase
14 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a multifunctional aminoacyl-tRNA synthetase that catalyzes the aminoacylation of glutamic acid and proline tRNA species. Alternative splicing has been observed for this gene, but the full-length nature and biological validity of the variant have not been determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
6.1.1.15; 6.1.1.17
KEGG - Orthology:
K01881
K01885
KEGG - Pathway(s):
hsa00860; hsa00970; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
PARS; Prolyl-tRNA synthetase; Bifunctional aminoacyl-tRNA synthetase; Glutamate tRNA ligase; GLUPRORS; QPRS; QARS; EC 6.1.1.17; EC 6.1.1.15
Approved Symbol:
EPRS
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 25
Human (de-) phosphorylation sites: 25; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • '5'-O-(N-(L-Alanyl)-Sulfamoyl)Adenosine(db);
  • '5'-O-(N-(L-Prolyl)-Sulfamoyl)Adenosine(db);
  • 5'-O-(N-(L-Cysteinyl)-Sulfamoyl)Adenosine(db);
  • L-Glutamic Acid(db);
  • L-Proline(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00703 Entrez Gene ID: 2058 OMIM ID: 138295 Swissprot Accession: P07814;