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Description for Protein EPHX2

epoxide hydrolase 2, cytoplasmic
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the epoxide hydrolase family. The protein, found in both the cytosol and peroxisomes, binds to specific epoxides and converts them to the corresponding dihydrodiols. Mutations in this gene have been associated with familial hypercholesterolemia. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
3.3.2.10
KEGG - Orthology:
K08726
KEGG - Pathway(s):
hsa00590; hsa01100; hsa04146
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
SEH; CEH; Epoxide hydratase; Soluble epoxide hydrolase; Cytosolic epoxide hydrolase; EC 3.3.2.3
Approved Symbol:
EPHX2
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 0
No human (de-) phosphorylation sites; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 4-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}BUTANOIC ACID(db);
  • 6-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEXANOIC ACID(db);
  • 7-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEPTANOIC ACID(db);
  • N-Cyclohexyl-N'-(4-Iodophenyl)Urea(db);
  • N-Cyclohexyl-N'-(Propyl)Phenyl Urea(db);
  • N-Cyclohexyl-N'-Decylurea(db);
  • N-[(CYCLOHEXYLAMINO)CARBONYL]GLYCINE(db)

    Associated Genetic Diseases:

  • Hypercholesterolemia, familial, due to ldlr defect, modifier of(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00582 Entrez Gene ID: 2053 OMIM ID: 132811 Swissprot Accession: P34913;