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Description for Protein EPHX1

epoxide hydrolase 1, microsomal (xenobiotic)
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(membrane: 1)
Summary:
Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene. (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
3.3.2.9
KEGG - Orthology:
K01253
KEGG - Pathway(s):
hsa00980
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Epoxide hydrolase 1, microsomal EPHX; Epoxide hydrolase, microsomal xenobiotic; EPOX; Epoxide hydratase
Approved Symbol:
EPHX1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 1
Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

  • Epoxide hydrolase polymorphism(Pd);
  • Hypercholanemia, familial(Pd);
  • Lymphoproliferative disorders, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00581 Entrez Gene ID: 2052 OMIM ID: 132810 Swissprot Accession: B2R8N0; P07099;