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Description for Protein EPHB2

EPH receptor B2
39 total interacting proteins; 18 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 5)
Summary:
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • FN3: Fibronectin type 3 domain
  • TM: Transmembrane domain
  • Tyr_Kinase: tyrosine kinase domain
  • SAM: Sterile alpha motif.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.10.1
    KEGG - Orthology:
    K05111
    KEGG - Pathway(s):
    hsa04360
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    EPHT3; HEK5; Tyro5; MGC87492; Elk related tyrosine kinase; Developmentally regulated eph related tyrosine kinase; EPH receptor B2; Ephrin receptor EphB2; DRT; ERK; EPH tyrosine kinase 3; Ephrin receptor EphB2 isoform 2; Ephrin receptor EphB2 isoform 1
    Approved Symbol:
    EPHB2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 58
    Human (de-) phosphorylation sites: 58; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 2
    Human phosphorylation targets: 2; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Phosphoaminophosphonic Acid-Adenylate Ester(db)

    Associated Genetic Diseases:

  • Prostate cancer, progression and metastasis of(Pd);
  • Prostate cancer, susceptibility to, in african americans(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 02997 Entrez Gene ID: 2048 OMIM ID: 600997 Swissprot Accession: P29323;