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Description for Protein EPB49

erythrocyte membrane protein band 4.9 (dematin)
11 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 6/2)
(membrane: 1; phosphoproteome: 1; platelet: 11; undefined: 1)
Summary:
Dematin, or EPB49, is an actin-bundling protein originally identified in the erythroid membrane skeleton. Its actin-bundling activity is abolished upon phosphorylation by cAMP-dependent protein kinase and is restored after dephosphorylation (Rana et al., 1993 [PubMed 8341682]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • VHP: Villin headpiece domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Erythrocyte membrane protein band 4.9; DMT
    Approved Symbol:
    EPB49
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 39
    Human (de-) phosphorylation sites: 39; Platelet phosphorylation sites: 14
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00506 Entrez Gene ID: 2039 OMIM ID: 125305 Swissprot Accession: Q08495; B3KRH3;