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Description for Protein SLC29A1

solute carrier family 29 (nucleoside transporters), member 1
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(membrane: 1)
Summary:
This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03323
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Equilibrative nucleoside transporter 1; ENT1
    Approved Symbol:
    SLC29A1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Troglitazone(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
    03724_5(11)
    03724_4(11)
    03724_3(11)
    03724_2(11)
    03724_1(11)
    Additional Identifiers:

    HPRD: 03724 Entrez Gene ID: 2030 OMIM ID: 602193 Swissprot Accession: Q99808;