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Description for Protein ENO3

enolase 3 (beta, muscle)
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 4/0)
(alpha granules: 1; membrane: 1; microparticles: 1; platelet: 1)
Summary:
This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme is found in skeletal muscle cells in the adult where it may play a role in muscle development and regeneration. A switch from alpha enolase to beta enolase occurs in muscle tissue during development in rodents. Mutations in this gene have be associated glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
4.2.1.11
KEGG - Orthology:
K01689
KEGG - Pathway(s):
hsa00010; hsa01100; hsa03018
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
MSE; Beta enolase; Enolase 3 beta muscle; Muscle specific enolase; Skeletal muscle enolase; 2 phospho D glycerate hydrolyase; Enolase 3 deficiency included; Enolase beta deficiency included; EC 4.2.1.11
Approved Symbol:
ENO3
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 6
Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 2-Phospho-D-Glyceric Acid(db);
  • Phosphoenolpyruvate(db);
  • Phosphoglycolic Acid(db);
  • Phosphonoacetohydroxamic Acid(db)

    Associated Genetic Diseases:

  • Enolase-beta deficiency(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 11746 Entrez Gene ID: 2027 OMIM ID: 131370 Swissprot Accession: P13929;