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Description for Protein ENO1

enolase 1, (alpha)
10 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 13/1)
(alpha granules: 1; membrane: 2; microparticles: 1; platelet: 8; secretome: 2)
Summary:
This gene encodes one of three enolase isoenzymes found in mammals; it encodes alpha-enolase, a homodimeric soluble enzyme, and also encodes a shorter monomeric structural lens protein, tau-crystallin. The two proteins are made from the same message. The full length protein, the isoenzyme, is found in the cytoplasm. The shorter protein is produced from an alternative translation start, is localized to the nucleus, and has been found to bind to an element in the c-myc promoter. A pseudogene has been identified that is located on the other arm of the same chromosome. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
4.2.1.11
KEGG - Orthology:
K01689
KEGG - Pathway(s):
hsa00010; hsa01100; hsa03018
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Enolase, alpha; Phosphopyruvate hydratase; PPH; Crystallin, tau; Enolase, nonneuronal; NNE; 2-phospho-D-glycerate hydrolyase; MYC promoter binding protein 1
Approved Symbol:
ENO1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 19
Human (de-) phosphorylation sites: 19; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01400 Entrez Gene ID: 2023 OMIM ID: 172430 Swissprot Accession: P06733;