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Description for Protein CTTN

cortactin
47 total interacting proteins; 32 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 8/3)
(microparticles: 1; phosphoproteome: 1; platelet: 6; secretome: 2; undefined: 2)
Summary:
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • SH3: Src homology 3 domains
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06106
    KEGG - Pathway(s):
    hsa04530; hsa05100; hsa05130; hsa05131
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Src substrate cortactin; Amplaxin; Oncogene EMS1; Cortactin isoform b; Cortactin isoform a
    Approved Symbol:
    CTTN
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 72
    Human (de-) phosphorylation sites: 72; Platelet phosphorylation sites: 10
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01268 Entrez Gene ID: 2017 OMIM ID: 164765 Swissprot Accession: Q14247; Q53HG7; Q96H99;