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Description for Protein MARK2

MAP/microtubule affinity-regulating kinase 2
38 total interacting proteins; 18 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(phosphoproteome: 1; undefined: 1)
Summary:
This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
  • UBA: Ubiquitin associated domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K08798
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    ELKL motif kinase 1; PAR1; MGC99619; EC 2.7.1.37; Serine/threonine protein kinase MARK2; MAP/microtubule affinity regulating kinase 2 isoform b; MAP/microtubule affinity-regulating kinase 2 isoform c; MAP/microtubule affinity-regulating kinase 2 isoform d; MAP/microtubule affinity regulating kinase 2 isoform a
    Approved Symbol:
    MARK2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 112
    Human (de-) phosphorylation sites: 112; Platelet phosphorylation sites: 1
    Phosphorylation Targets:
    Total phosphorylation targets: 7
    Human phosphorylation targets: 7; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02753 Entrez Gene ID: 2011 OMIM ID: 600526 Swissprot Accession: Q7KZI7; A8K2S4;