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Description for Protein ELF5

E74-like factor 5 (ets domain transcription factor)
5 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of an epithelium-specific subclass of the Ets transcritpion factor family. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • ETS: erythroblast transformation specific domain
  • SAM_PNT: SAM / Pointed domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K09429
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    E74 like factor 5, ets domain transcription factor; Epithelium specific ETS factor 2; ESE2; Epithelium specific Ets transcription factor 2; E74 like factor 5 ESE-2b; E74 like factor 5 ESE-2a
    Approved Symbol:
    ELF5
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05525 Entrez Gene ID: 2001 OMIM ID: 605169 Swissprot Accession: Q9UKW6; A8K443;