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Description for Protein ELF4

E74-like factor 4 (ets domain transcription factor)
9 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
The protein encoded by this gene is a transcriptional activator that binds and activates the promoters of the CSF2, IL3, IL8, and PRF1 genes. The encoded protein is involved in natural killer cell development and function, innate immunity, and induction of cell cycle arrest in naive CD8+ cells. Two transcript variants encoding the same protein have been found for this gene. (PubMed Links)
Domains and Motifs:
  • NLS: Nuclear localization signal
  • ETS: erythroblast transformation specific domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K09428
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    E74 like factor 4 (ets domain transcription factor); Myeloid elf 1 like factor; MEF
    Approved Symbol:
    ELF4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 11
    Human (de-) phosphorylation sites: 11; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06499 Entrez Gene ID: 2000 OMIM ID: 300775 Swissprot Accession: Q99607;