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Description for Protein ELANE

elastase, neutrophil expressed
31 total interacting proteins; 20 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 1)
Summary:
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TRYPSIN: Trypsin-like serine protease
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.21.37
    KEGG - Orthology:
    K01327
    KEGG - Pathway(s):
    hsa05322
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Elastase 2; Elastase, neutrophil; NE; Medullasin; Protease, serine, bone marrow; HLE
    Approved Symbol:
    ELANE
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Alpha-1-proteinase inhibitor(db);
  • Filgrastim(db);
  • Fucose(db);
  • Mdl 101,146(db);
  • ONO-6818(db);
  • Pegfilgrastim(db)

    Associated Genetic Diseases:

  • Cyclic hematopoiesis(Pd);
  • Neutropenia, severe congenital, autosomal dominant 1(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00554 Entrez Gene ID: 1991 OMIM ID: 130130 Swissprot Accession: P08246;