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Description for Protein AIF1

allograft inflammatory factor 1
2 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene is induced by cytokines and interferon. Its protein product is thought to be involved in negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • EF: EF-hand, calcium binding motif
  • NLS: Nuclear localization signal
  • LZ: Leucine Zipper
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Allograft inflammatory factor 1 isoform 1; Interferon response transcript 1; IRT; Ionized calcium binding adapter molecule 1; IBA1; Interferon gamma responsive transcript; AIF-1; IRT-1; G1; Allograft inflammatory factor 1 isoform 2; Allograft inflammatory factor 1 isoform 3
    Approved Symbol:
    AIF1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03496 Entrez Gene ID: 199 OMIM ID: 601833 Swissprot Accession: O43904; Q9UIV4; P55008;