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Description for Protein EIF4G2

eukaryotic translation initiation factor 4 gamma, 2
12 total interacting proteins; 9 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 4/1)
(membrane: 1; phosphoproteome: 1; platelet: 3; undefined: 1)
Summary:
Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • MIF4G: Middle domain of eukaryotic initiation factor 4G (eIF4G)
  • MA3: Domain in DAP-5, eIF4G, MA-3 and other proteins.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03260
    KEGG - Pathway(s):
    hsa05416
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Eukaryotic translation initiation factor 4 gamma 2; EIF-4-gamma 2; EIF-4G 2; p97; Death associated protein 5; DAP 5; NAT1; Eukaryotic translation initiation factor 4G-like 1; Eukaryotic translation initiation factor 4 gamma, 2 isoform 2
    Approved Symbol:
    EIF4G2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 19
    Human (de-) phosphorylation sites: 19; Platelet phosphorylation sites: 1
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09084 Entrez Gene ID: 1982 OMIM ID: 602325 Swissprot Accession: P78344;