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Description for Protein EIF4G1

eukaryotic translation initiation factor 4 gamma, 1
30 total interacting proteins; 20 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 4/1)
(phosphoproteome: 1; platelet: 25; undefined: 1)
Summary:
The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • MA3: Domain in DAP-5, eIF4G, MA-3 and other proteins.
  • CC: Coiled Coil
  • NLS: Nuclear localization signal
  • MIF4G: Middle domain of eukaryotic initiation factor 4G (eIF4G)
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03260
    KEGG - Pathway(s):
    hsa05416
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Eukaryotic translation initiation factor 4 gamma, 1; Eukaryotic translation initiation factor 4 G; eIF 4 gamma 1; eIF4G; p220; DKFZp686A1451; EIF4F; Eukaryotic translation initiation factor 4 gamma, 1 isoform 1; Eukaryotic translation initiation factor 4 gamma, 1 isoform 2; Eukaryotic translation initiation factor 4 gamma, 1 isoform 3; Eukaryotic translation initiation factor 4 gamma, 1 isoform 4
    Approved Symbol:
    EIF4G1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 132
    Human (de-) phosphorylation sites: 132; Platelet phosphorylation sites: 4
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06774 Entrez Gene ID: 1981 OMIM ID: 600495 Swissprot Accession: Q04637;