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Description for Protein EIF4EBP1

eukaryotic translation initiation factor 4E binding protein 1
26 total interacting proteins; 15 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(platelet: 1; undefined: 1)
Summary:
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K07205
KEGG - Pathway(s):
hsa04012; hsa04150; hsa04910; hsa05221
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
BP-1; EIF4E-binding protein 1; PHAS-I; MGC4316; Phosphorylated heat- and acid-stable protein regulated by insulin 1; 4EBP1
Approved Symbol:
EIF4EBP1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 23
Human (de-) phosphorylation sites: 23; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03746 Entrez Gene ID: 1978 OMIM ID: 602223 Swissprot Accession: Q13541;