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Description for Protein EIF2S1

eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
22 total interacting proteins; 14 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/0)
(platelet: 5)
Summary:
The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • S1: Ribosomal protein S1-like RNA-binding domain
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03237
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    EIF2, alpha 1; eIF-2-alpha; Eukaryotic translation initiation factor 2, subunit 1 alpha; Eukaryotic translation initiation factor 2 alpha; eIF-2, alpha; EIF2-alpha
    Approved Symbol:
    EIF2S1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 7
    Human (de-) phosphorylation sites: 7; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04881 Entrez Gene ID: 1965 OMIM ID: 603907 Swissprot Accession: P05198; Q53XC0;