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Description for Protein EHHADH

enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(membrane: 1; platelet: 1)
Summary:
The protein encoded by this gene is a bifunctional enzyme and is one of the four enzymes of the peroxisomal beta-oxidation pathway. The N-terminal region of the encoded protein contains enoyl-CoA hydratase activity while the C-terminal region contains 3-hydroxyacyl-CoA dehydrogenase activity. Defects in this gene are a cause of peroxisomal disorders such as Zellweger syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.1.1.35; 4.2.1.17; 5.3.3.8
KEGG - Orthology:
K07514
KEGG - Pathway(s):
hsa00071; hsa00280; hsa00310; hsa00380; hsa00410; hsa00640; hsa00650; hsa00903; hsa01100; hsa03320; hsa04146
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
LBP; Enoyl CoA hydratase/3 hydroxyacyl CoA dehydrogenase; EHHADH L bifunctional protein, peroxisomal; LBFP; PBE; PBFE; Enoyl CoA hydratase; 3,2 trans enoyl CoA isomerase; 3 hydroxyacyl CoA dehydrogenase
Approved Symbol:
EHHADH
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 1
Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • NADH(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06125 Entrez Gene ID: 1962 OMIM ID: 607037 Swissprot Accession: Q08426; B4DWG3;