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Description for Protein AHR

aryl hydrocarbon receptor
32 total interacting proteins; 13 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
This gene encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Its ligands included a variety of aromatic hydrocarbons. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PAS: PAS domain
  • NLS: Nuclear localization signal
  • HLH: helix loop helix domain
  • PAC: Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)
  • NES: Nuclear Export Signal
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K09093
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Ah receptor; Dioxin receptor
    Approved Symbol:
    AHR
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Atorvastatin(db);
  • Flutamide(db);
  • Ginseng(db);
  • Leflunomide(db);
  • Mexiletine(db);
  • Nimodipine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02596 Entrez Gene ID: 196 OMIM ID: 600253 Swissprot Accession: P35869;