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Description for Protein EGFR

epidermal growth factor receptor
256 total interacting proteins; 159 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • FU: Furin-like repeats
  • REC: cheY-homologous receiver domain
  • TM: Transmembrane domain
  • Tyr_Kinase: tyrosine kinase domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.10.1
    KEGG - Orthology:
    K04361
    KEGG - Pathway(s):
    hsa04010; hsa04012; hsa04020; hsa04060; hsa04144; hsa04320; hsa04510; hsa04520; hsa04540; hsa04810; hsa04912; hsa05120; hsa05200; hsa05212; hsa05213; hsa05214; hsa05215; hsa05218; hsa05219; hsa05223
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Epidermal growth factor receptor isoform d; Epidermal growth factor receptor isoform b; Epidermal growth factor receptor isoform c; Epidermal growth factor receptor isoform a; ERBB1; mENA; p170; EC 2.7.1.112; Receptor tyrosine protein kinase ErbB-1; Truncated epidermal growth factor receptor; Species antigen 7
    Approved Symbol:
    EGFR
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 50
    Human (de-) phosphorylation sites: 50; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 35
    Human phosphorylation targets: 35; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 3-CHLORO-4-FLUORO-N-[(4Z)-7-METHOXY-6-(3-MORPHOLIN-4-YLPROPOXY)QUINAZOLIN-4(1H)-YLIDENE]ANILINE(db);
  • Cetuximab(db);
  • Erlotinib(db);
  • Flavopiridol(db);
  • Gefitinib(db);
  • Lapatinib(db);
  • Lidocaine(db);
  • N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE(db);
  • N-{3-Chloro-4-[(3-Fluorobenzyl)Oxy]Phenyl}-6-[5-({[2-(Methylsulfonyl)Ethyl]Amino}Methyl)-2-Furyl]-4-Quinazolinamine(db);
  • Panitumumab(db);
  • S-{3-[(4-ANILINOQUINAZOLIN-6-YL)AMINO]-3-OXOPROPYL}-L-CYSTEINE(db);
  • Trastuzumab(db)

    Associated Genetic Diseases:

  • Nonsmall cell lung cancer, resistance to tyrosine kinase inhibitor in(Pd);
  • Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, somatic(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 2
    • Additional Identifiers:

    HPRD: 00579 Entrez Gene ID: 1956 OMIM ID: 131550 Swissprot Accession: P00533;