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Description for Protein CELSR3

cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
11 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • Cadherin: Cadherin repeats
  • EGFL: EGF domain, unclasssified subfamily
  • LAMG: Laminin G domain
  • EGFLAM: Laminin-type epidermal growth factor-like domain
  • GPS: G-protein-coupled receptor proteolytic site domain
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04602
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    CDHF11; EGFL1; FMI1; HFMI1; MEGF2; EGF like domain, multiple 1; Cadherin, EGF LAG seven pass G type receptor 3; Multiple EGF like domains 2
    Approved Symbol:
    CELSR3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 6
    • Additional Identifiers:

    HPRD: 09179 Entrez Gene ID: 1951 OMIM ID: 604264 Swissprot Accession: Q9NYQ7;