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Description for Protein EGF

epidermal growth factor
16 total interacting proteins; 9 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/1)
(alpha granules: 1; membrane: 1; platelet: 4)
Summary:
This gene encodes a member of the epidermal growth factor superfamily. The encoded protein is synthesized as a large precursor molecule that is proteolytically cleaved to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding the high affinity cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternate splicing results in multiple transcript variants. (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
  • EGFL: EGF domain, unclasssified subfamily
  • EGFCA: Calcium-binding EGF-like domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04357
    KEGG - Pathway(s):
    hsa04010; hsa04012; hsa04060; hsa04144; hsa04510; hsa04540; hsa04810; hsa05200; hsa05212; hsa05213; hsa05214; hsa05215; hsa05218; hsa05219; hsa05223
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Urogastrone; URG
    Approved Symbol:
    EGF
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Alpha-Aminobutyric Acid(db);
  • Sucralfate(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00578 Entrez Gene ID: 1950 OMIM ID: 131530 Swissprot Accession: P01133;