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Description for Protein EEF1D

eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
24 total interacting proteins; 15 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 5/0)
(platelet: 12; secretome: 2)
Summary:
This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit, delta, functions as guanine nucleotide exchange factor. It is reported that following HIV-1 infection, this subunit interacts with HIV-1 Tat. This interaction results in repression of translation of host cell proteins and enhanced translation of viral proteins. Several alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. Related pseudogenes have been defined on chromosomes 1, 6, 7, 9, 11, 13, 17, 19. (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03232
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Eukaryotic translation elongation factor 1 delta isoform 2; Elongation factor 1, delta; EF1D; Guanine nucleotide exchange protein; EF1 delta; FP1047; FLJ20897
    Approved Symbol:
    EEF1D
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 42
    Human (de-) phosphorylation sites: 42; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 7 : 0
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00560 Entrez Gene ID: 1936 OMIM ID: 130592 Swissprot Accession: P29692; B2RAR6; Q9H7G6;