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Description for Protein EEF1A1

eukaryotic translation elongation factor 1 alpha 1
99 total interacting proteins; 38 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 5/1)
(membrane: 1; platelet: 4; secretome: 4)
Summary:
This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
3.6.5.3
KEGG - Orthology:
K03231
KEGG - Pathway(s):
None Available
Nomenclature / Alternative Names:
CCS3; CCS-3; EEF-1; Elongation factor 1 alpha; EF1A; EEF1A; Eukaryotic translation elongation factor 1 alpha 1; EF 1 alpha 1; Elongation factor 1 A 1; eEF1A 1; Elongation factor Tu; EF Tu; CTCL tumor antigen; Glucocorticoid receptor AF 1 specific elongation factor; Translation elongation factor 1 alpha 1 like 14; PTI1; LENG7; GRAF 1EF; MGC16224; HNGC:16303; Prostate tumor inducing protein 1; Leukocyte receptor cluster LRC member 7
Approved Symbol:
EEF1A1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 16
Human (de-) phosphorylation sites: 16; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Guanosine-5'-Diphosphate(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00559 Entrez Gene ID: 1915 OMIM ID: 130590 Swissprot Accession: P68104; Q6IPS9;