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Description for Protein AHCY

adenosylhomocysteinase
4 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(microparticles: 1; secretome: 1)
Summary:
S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
3.3.1.1
KEGG - Orthology:
K01251
KEGG - Pathway(s):
hsa00270; hsa00450; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
S adenosyl L homocysteine hydrolase; SAHH
Approved Symbol:
AHCY
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 1
Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • (1'r,2's)-9-(2-Hydroxy-3'-Keto-Cyclopenten-1-Yl)Adenine(db);
  • 3'-Oxo-Adenosine(db);
  • D-Eritadenine(db);
  • Isopropyl Alcohol(db);
  • Nicotinamide-Adenine-Dinucleotide(db)

    Associated Genetic Diseases:

  • Hypermethioninemia with deficiency of s-adenosylhomocysteine hydrolase(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01621 Entrez Gene ID: 191 OMIM ID: 180960 Swissprot Accession: P23526; B3KUN3;