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Description for Protein EDNRA

endothelin receptor type A
7 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04197
    KEGG - Pathway(s):
    hsa04020; hsa04080; hsa04270
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Endothelin receptor, ET1 specific type; ETA; ETRA
    Approved Symbol:
    EDNRA
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 15
    Human (de-) phosphorylation sites: 15; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 2-HYDROXY-3,5-DIIODOBENZOIC ACID(db);
  • Bosentan(db);
  • Sitaxentan(db)

    Associated Genetic Diseases:

  • Migraine, resistance to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 00571 Entrez Gene ID: 1909 OMIM ID: 131243 Swissprot Accession: P25101;