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Description for Protein LPAR1

lysophosphatidic acid receptor 1
4 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Two transcript variants encoding the same protein have been identified for this gene [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04289
    KEGG - Pathway(s):
    hsa04080; hsa04540
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Lysophosphatidic acid receptor Edg2; LPA receptor Edg2; Lysophosphatidic acid G protein coupled receptor 2; Ventricular zone gene 1; LPA1 receptor; LPA1; VZG1; Endothelial differentiation lysophosphatidic acid G protein coupled receptor 2; Gpcr26; LPAR1; Mrec1.3; Edg 2; rec.1.3
    Approved Symbol:
    LPAR1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 7
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 03790 Entrez Gene ID: 1902 OMIM ID: 602282 Swissprot Accession: Q92633; Q5VZX0;