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Description for Protein ECHS1

enoyl CoA hydratase, short chain, 1, mitochondrial
5 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/0)
(platelet: 2; secretome: 1)
Summary:
The protein encoded by this gene functions in the second step of the mitochondrial fatty acid beta-oxidation pathway. It catalyzes the hydration of 2-trans-enoyl-coenzyme A (CoA) intermediates to L-3-hydroxyacyl-CoAs. The gene product is a member of the hydratase/isomerase superfamily. It localizes to the mitochondrial matrix. Transcript variants utilizing alternative transcription initiation sites have been described in the literature. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    4.2.1.17
    KEGG - Orthology:
    K07511
    KEGG - Pathway(s):
    hsa00062; hsa00071; hsa00280; hsa00310; hsa00380; hsa00410; hsa00640; hsa00650; hsa00903; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Enoyl Coenzyme A hydratase, short chain 1, mitochondrial; SCEH
    Approved Symbol:
    ECHS1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 4-(N,N-Dimethylamino)Cinnamoyl-Coa(db);
  • Acetoacetyl-Coenzyme A(db);
  • Hexanoyl-Coenzyme A(db);
  • Octanoyl-Coenzyme A(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03799 Entrez Gene ID: 1892 OMIM ID: 602292 Swissprot Accession: P30084;