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Description for Protein TYMP

thymidine phosphorylase
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 7/1)
(membrane: 1; microparticles: 1; platelet: 5; secretome: 1; undefined: 1)
Summary:
This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.4.2.4
KEGG - Orthology:
K00758
KEGG - Pathway(s):
hsa00240; hsa00983; hsa01100; hsa05219
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
TdRPase; TP; Thymidine phosphorylase; Gliostatin; PDECGF
Approved Symbol:
TYMP
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 1
Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 5-Chloro-6-[(2-Iminopyrrolidin-1-Yl)Methyl]Pyrimidine-2,4(1h,3h)-Dione(db)

    Associated Genetic Diseases:

  • Mitochondrial neurogastrointestinal encephalomyopathy syndrome(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 08833 Entrez Gene ID: 1890 OMIM ID: 131222 Swissprot Accession: P19971; B2RBL3;