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Description for Protein AGXT

alanine-glyoxylate aminotransferase
2 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.6.1.44; 2.6.1.51
KEGG - Orthology:
K00830
KEGG - Pathway(s):
hsa00250; hsa00260; hsa01100; hsa04146
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
AGT; SPT; SPAT; Serine pyruvate aminotransferase
Approved Symbol:
AGXT
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 1
Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • (Aminooxy)Acetic Acid(db);
  • 4-(2-AMINOPHENYL)-4-OXOBUTANOIC ACID(db);
  • Glycine(db);
  • L-Alanine(db);
  • L-Serine(db);
  • N'-Pyridoxyl-Lysine-5'-Monophosphate(db);
  • Pyridoxal Phosphate(db)

    Associated Genetic Diseases:

  • Hyperoxaluria, primary, type I(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05048 Entrez Gene ID: 189 OMIM ID: 604285 Swissprot Accession: P21549;