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Description for Protein DYRK1A

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
17 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • NLS: Nuclear localization signal
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
  • LZ: Leucine Zipper
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.12.1
    KEGG - Orthology:
    K08825
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Dual specificity tyrosine (Y) phosphorylation regulated kinase 1A isoform 2; Dual specificity tyrosine (Y) phosphorylation regulated kinase 1A isoform 3; Dual specificity tyrosine (Y) phosphorylation regulated kinase 1A isoform 4; Dual specificity tyrosine (Y) phosphorylation regulated kinase 1A isoform 5; DYRK; Minibrain homolog; Protein kinase minibrain homolog; MNBH; Dual specificity YAK1-related kinase; Mnb protein kinase homolog hp86; MNB/DYRK protein kinase; HP86; MNB; Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A isoform 1
    Approved Symbol:
    DYRK1A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 27
    Human (de-) phosphorylation sites: 27; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 10
    Human phosphorylation targets: 10; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09018 Entrez Gene ID: 1859 OMIM ID: 600855 Swissprot Accession: Q13627;