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Description for Protein AGTR1

angiotensin II receptor, type 1
20 total interacting proteins; 13 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. At least five transcript variants have been described for this gene. Additional variants have been described but their full-length nature has not been determined. The entire coding sequence is contained in the terminal exon and is present in all transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04166
    KEGG - Pathway(s):
    hsa04020; hsa04080; hsa04270; hsa04614
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Angiotensin II receptor vascular type 1; AT2R1; AT1; AG2S; HAT1RB; Angiotensin II receptor, type 1; Angiotensin receptor 1B; Type-1B angiotensin II receptor
    Approved Symbol:
    AGTR1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Candesartan(db);
  • Eprosartan(db);
  • Forasartan(db);
  • Irbesartan(db);
  • Losartan(db);
  • Olmesartan(db);
  • Saprisartan(db);
  • Tasosartan(db);
  • Telmisartan(db);
  • Valsartan(db)

    Associated Genetic Diseases:

  • Hypertension, essential, susceptibility to(Pd);
  • Renal tubular dysgenesis(Pd);
  • Stature as a quantitative trait(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 5 : 7
  • Isoform 4 : 7
  • Isoform 3 : 7
  • Isoform 2 : 7
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 00107 Entrez Gene ID: 185 OMIM ID: 106165 Swissprot Accession: P30556; Q53YY0;