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Description for Protein RCAN1

regulator of calcineurin 1
6 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
None Available
KEGG - Pathway(s):
None Available
Nomenclature / Alternative Names:
MCIP1; ADAPT78; Down syndrome critical region gene 1; Near DSCR proline rich protein; Down syndrome candidate region 1; Human Down syndrome candidate region protein, proline-rich protein; Myocyte enriched calcineurin interacting protein; Modulatory calcineurin interacting protein; Down syndrome critical region protein 1; CSP1; DSC1; RCN1; Calcipressin 1 isoform c; Calcipressin 1 isoform b; Calcipressin 1 isoform a
Approved Symbol:
RCAN1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 8
Human (de-) phosphorylation sites: 8; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04226 Entrez Gene ID: 1827 OMIM ID: 602917 Swissprot Accession: P53805; Q6FGP2;