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Description for Protein JAG1

jagged 1
9 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
  • DSL: delta serrate ligand
  • EGFL: EGF domain, unclasssified subfamily
  • EGFCA: Calcium-binding EGF-like domain
  • VWC: von Willebrand factor (vWF) type C domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06052
    KEGG - Pathway(s):
    hsa04330
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    JAGL1; hJ1
    Approved Symbol:
    JAG1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Alagille syndrome 1(Pd);
  • Deafness, congenital heart defects, and posterior embryotoxon(Pd);
  • Tetralogy of fallot(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 03562 Entrez Gene ID: 182 OMIM ID: 601920 Swissprot Accession: Q99740; P78504;