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Description for Protein DRD5

dopamine receptor D5
5 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05840
    KEGG - Pathway(s):
    hsa04020; hsa04080
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    D1 beta dopamine receptor
    Approved Symbol:
    DRD5
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Apomorphine(db);
  • Aripiprazole(db);
  • Bromocriptine(db);
  • Cabergoline(db);
  • Carphenazine(db);
  • Dopamine(db);
  • Fenoldopam(db);
  • Levodopa(db);
  • Lisuride(db);
  • Methotrimeprazine(db);
  • Olanzapine(db);
  • Pergolide(db);
  • Pramipexole(db);
  • Quetiapine(db);
  • Ropinirole(db);
  • Rotigotine Transdermal Patch(db);
  • Ziprasidone(db);
  • Zuclopenthixol(db)

    Associated Genetic Diseases:

  • Attention deficit-hyperactivity disorder, susceptibility to(Pd);
  • Blepharospasm(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 6
    • Additional Identifiers:

    HPRD: 00542 Entrez Gene ID: 1816 OMIM ID: 126453 Swissprot Accession: P21918;