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Description for Protein DRD4

dopamine receptor D4
9 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04147
    KEGG - Pathway(s):
    hsa04080
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    D4DR
    Approved Symbol:
    DRD4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Apomorphine(db);
  • Aripiprazole(db);
  • Bromocriptine(db);
  • Cabergoline(db);
  • Clozapine(db);
  • Dopamine(db);
  • Levodopa(db);
  • Lisuride(db);
  • Methotrimeprazine(db);
  • Olanzapine(db);
  • Paliperidone(db);
  • Pergolide(db);
  • Pramipexole(db);
  • Promazine(db);
  • Propiomazine(db);
  • Quetiapine(db);
  • Remoxipride(db);
  • Risperidone(db);
  • Ropinirole(db);
  • Rotigotine Transdermal Patch(db);
  • Thiethylperazine(db);
  • Ziprasidone(db)

    Associated Genetic Diseases:

  • Attention deficit-hyperactivity disorder, susceptibility to(Pd);
  • Autonomic nervous system dysfunction(Pd);
  • Dopamine receptor D4 polymorphism(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 00541 Entrez Gene ID: 1815 OMIM ID: 126452 Swissprot Accession: P21917;