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Description for Protein DRD3

dopamine receptor D3
14 total interacting proteins; 10 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04146
    KEGG - Pathway(s):
    hsa04080
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Dopamine receptor D3 isoform c; Dopamine receptor D3 isoform d; Dopamine receptor D3 isoform e; Dopamine receptor D3 isoform a
    Approved Symbol:
    DRD3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 8
    Human (de-) phosphorylation sites: 8; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Amisulpride(db);
  • Apomorphine(db);
  • Aripiprazole(db);
  • Bromocriptine(db);
  • Cabergoline(db);
  • Chlorprothixene(db);
  • Clozapine(db);
  • Domperidone(db);
  • Dopamine(db);
  • Haloperidol(db);
  • Levodopa(db);
  • Lisuride(db);
  • Methotrimeprazine(db);
  • Olanzapine(db);
  • Paliperidone(db);
  • Pergolide(db);
  • Pimozide(db);
  • Pramipexole(db);
  • Quetiapine(db);
  • Remoxipride(db);
  • Risperidone(db);
  • Ropinirole(db);
  • Rotigotine Transdermal Patch(db);
  • Sulpiride(db);
  • Yohimbine(db);
  • Ziprasidone(db)

    Associated Genetic Diseases:

  • Schizophrenia, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 5 : 7
  • Isoform 4 : 5
  • Isoform 3 : 5
  • Isoform 2 : 4
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 00540 Entrez Gene ID: 1814 OMIM ID: 126451 Swissprot Accession: P35462;