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Description for Protein DRD2

dopamine receptor D2
22 total interacting proteins; 14 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04145
    KEGG - Pathway(s):
    hsa04080; hsa04540
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Dopamine receptor D2 isoform short; Dopamine receptor D2 isoform long; D2R
    Approved Symbol:
    DRD2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 9
    Human (de-) phosphorylation sites: 9; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Acepromazine(db);
  • Acetophenazine(db);
  • Alizapride(db);
  • Amantadine(db);
  • Amisulpride(db);
  • Amoxapine(db);
  • Aniracetam(db);
  • Apomorphine(db);
  • Aripiprazole(db);
  • Bromocriptine(db);
  • Buspirone(db);
  • Cabergoline(db);
  • Carphenazine(db);
  • Chlorpromazine(db);
  • Chlorprothixene(db);
  • Cinnarizine(db);
  • Clozapine(db);
  • Domperidone(db);
  • Dopamine(db);
  • Doxepin(db);
  • Droperidol(db);
  • Ergotamine(db);
  • Flupenthixol(db);
  • Fluphenazine(db);
  • Fluspirilene(db);
  • Haloperidol(db);
  • Ketamine(db);
  • Levodopa(db);
  • Lisuride(db);
  • Loxapine(db);
  • Mesoridazine(db);
  • Methotrimeprazine(db);
  • Metoclopramide(db);
  • Minaprine(db);
  • Molindone(db);
  • Olanzapine(db);
  • Paliperidone(db);
  • Pergolide(db);
  • Perphenazine(db);
  • Pimozide(db);
  • Pipotiazine(db);
  • Pramipexole(db);
  • Prochlorperazine(db);
  • Promazine(db);
  • Promethazine(db);
  • Propiomazine(db);
  • Quetiapine(db);
  • Remoxipride(db);
  • Risperidone(db);
  • Rolicyclidine(db);
  • Ropinirole(db);
  • Rotigotine Transdermal Patch(db);
  • Sertindole(db);
  • Sulpiride(db);
  • Thiethylperazine(db);
  • Thioproperazine(db);
  • Thioridazine(db);
  • Thiothixene(db);
  • Trifluoperazine(db);
  • Triflupromazine(db);
  • Trimipramine(db);
  • Yohimbine(db);
  • Ziprasidone(db);
  • Zuclopenthixol(db)

    Associated Genetic Diseases:

  • Myoclonus-dystonia syndrome(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 7
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 00539 Entrez Gene ID: 1813 OMIM ID: 126450 Swissprot Accession: P14416;