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Description for Protein DRD1

dopamine receptor D1
10 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04144
    KEGG - Pathway(s):
    hsa04020; hsa04080; hsa04540
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    DRD1A
    Approved Symbol:
    DRD1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Acepromazine(db);
  • Acetophenazine(db);
  • Amoxapine(db);
  • Apomorphine(db);
  • Aripiprazole(db);
  • Bromocriptine(db);
  • Cabergoline(db);
  • Carphenazine(db);
  • Chlorpromazine(db);
  • Chlorprothixene(db);
  • Clozapine(db);
  • Dihydroergotoxine(db);
  • Dopamine(db);
  • Fenoldopam(db);
  • Flupenthixol(db);
  • Fluphenazine(db);
  • Haloperidol(db);
  • Levodopa(db);
  • Lisuride(db);
  • Loxapine(db);
  • Methotrimeprazine(db);
  • Methylergonovine(db);
  • Minaprine(db);
  • Olanzapine(db);
  • Paliperidone(db);
  • Pergolide(db);
  • Perphenazine(db);
  • Phenylpropanolamine(db);
  • Pipotiazine(db);
  • Pramipexole(db);
  • Promazine(db);
  • Propericiazine(db);
  • Propiomazine(db);
  • Quetiapine(db);
  • Risperidone(db);
  • Ropinirole(db);
  • Rotigotine Transdermal Patch(db);
  • Thiethylperazine(db);
  • Thioproperazine(db);
  • Thioridazine(db);
  • Thiothixene(db);
  • Triflupromazine(db);
  • Trimipramine(db);
  • Ziprasidone(db);
  • Zuclopenthixol(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 00538 Entrez Gene ID: 1812 OMIM ID: 126449 Swissprot Accession: P21728;