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Description for Protein DOK1

docking protein 1, 62kDa (downstream of tyrosine kinase 1)
35 total interacting proteins; 28 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/1)
(membrane: 1; phosphoproteome: 1; platelet: 1; undefined: 1)
Summary:
The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PTBI: Phosphotyrosine-binding domain (IRS1-like)
  • PH: Pleckstrin homology domain.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Docking protein, 62-KD; p62DOK; Downstream of tyrosine kinase 1; pp62
    Approved Symbol:
    DOK1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 20
    Human (de-) phosphorylation sites: 20; Platelet phosphorylation sites: 1
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04228 Entrez Gene ID: 1796 OMIM ID: 602919 Swissprot Accession: Q99704;