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Description for Protein DNTT

deoxynucleotidyltransferase, terminal
8 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • BRCT: breast cancer carboxy-terminal domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.7.31
    KEGG - Orthology:
    K00977
    KEGG - Pathway(s):
    hsa03450; hsa04640
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Terminal deoxynucleotidyltransferase; Terminal addition enzyme; TDT; Nucleosidetriphosphate:DNA deoxynucleotidylexotransferase; Deoxynucleotidyltransferase terminal; Terminal deoxyribonucleotidyltransferase; Terminal transferase; Terminal deoxynucleotidyltransferase isoform 1; Terminal deoxynucleotidyltransferase isoform 2; EC 2.7.7.31
    Approved Symbol:
    DNTT
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 2',3'-Dideoxyadenosine-5'-Triphosphate(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 08925 Entrez Gene ID: 1791 OMIM ID: 187410 Swissprot Accession: P04053;