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Description for Protein DNMT3A

DNA (cytosine-5-)-methyltransferase 3 alpha
24 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PWWP: domain with conserved PWWP motif
  • PHD: PHD zinc finger
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.1.1.37
    KEGG - Orthology:
    K00558
    KEGG - Pathway(s):
    hsa00270; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    M.Hsa3A; DNA MTase Hsa3A; DNA methyltransferase Hsa3A; DNA cytosine methyltransferase 3A2; EC 2.1.1.37; DNA cytosine methyltransferase 3 alpha isoform a; DNA cytosine methyltransferase 3 alpha isoform c; DNA cytosine methyltransferase 3 alpha isoform b
    Approved Symbol:
    DNMT3A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 8
    Human (de-) phosphorylation sites: 8; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04141 Entrez Gene ID: 1788 OMIM ID: 602769 Swissprot Accession: Q86TE8; Q8WVA9; Q9Y6K1;