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Description for Protein DNMT1

DNA (cytosine-5-)-methyltransferase 1
30 total interacting proteins; 9 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(platelet: 2)
Summary:
DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • BAH: Bromo adjacent homology domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.1.1.37
    KEGG - Orthology:
    K00558
    KEGG - Pathway(s):
    hsa00270; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    DNA methyltransferase; DNMT; DNA cytosine 5 methyltransferase; MCMT; DNA cytosine 5 methyltransferase 1; DNA methyltransferase HsaI; DNA MTase HsaI; M.HsaI
    Approved Symbol:
    DNMT1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 30
    Human (de-) phosphorylation sites: 30; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Azacitidine(db);
  • Decitabine(db);
  • Flucytosine(db);
  • Procainamide(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00532 Entrez Gene ID: 1786 OMIM ID: 126375 Swissprot Accession: P26358;