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Description for Protein DNM2

dynamin 2
46 total interacting proteins; 30 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/0)
(membrane: 1; microparticles: 1; platelet: 6)
Summary:
Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PH: Pleckstrin homology domain.
  • DYNC: Dynamin, GTPase
  • GED: Dynamin GTPase effector domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.6.5.5
    KEGG - Orthology:
    K01528
    KEGG - Pathway(s):
    hsa04144; hsa04666; hsa05100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Dynamin 2 isoform 4; Dynamin 2 isoform 1; Dynamin 2 isoform 2; CMTDI1; CMTDIB; DYN2; DYNII; Dynamin 2 isoform 3
    Approved Symbol:
    DNM2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 30
    Human (de-) phosphorylation sites: 30; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Charcot-Marie-tooth disease, dominant intermediate B(Pd);
  • Charcot-Marie-tooth disease, dominant intermediate B, with neutropenia(Pd);
  • Myopathy, centronuclear, autosomal dominant(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03852 Entrez Gene ID: 1785 OMIM ID: 602378 Swissprot Accession: Q8N1K8; P50570; Q6ZSZ9;